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The media sometimes represents Lyme disease as a prolonged and debilitating condition. In reality, Lyme disease is easy to treat, especially if you catch it early. Most people find their symptoms resolve within a few weeks.

If you test positive for Lyme disease, you’ll need antibiotics to clear the infection. Your doctor may prescribe antibiotics without a test if it’s likely you have the disease. (You may not need a test if you received a tick bite in a Lyme-endemic area and have the characteristic rash, for example.)

The standard treatment for Lyme disease is 10 to 14 days of antibiotics. Doctors usually prescribe doxycycline, amoxicillin, or cefuroxime. (You may see a different name since these medications come as both generic and brand names.)

Typically, you’ll need to take the drugs by mouth twice per day. In some cases, your doctor may prescribe a drug that’s taken three times per day.

While all drugs can have unwanted side effects, the side effects of these drugs are usually mild. They can include constipation, headache, and diarrhea, among others. If you experience any side effects that concern you, let your doctor know.

Be sure to let your doctor know if you are pregnant or breastfeeding, so they can ensure the antibiotic prescribed is safe for you. Your doctor will also consider your other health conditions and allergies when choosing an antibiotic.

Treatment for More Serious Forms of Lyme Disease

If you have had Lyme disease for many months, the bacteria may be more pervasive in your body. It may cause more serious conditions, such as brain inflammation, a heart infection, or arthritis.

Fortunately, these more serious complications are rare. For example, the heart infection known as Lyme carditis occurs in 1 out of 100 people with Lyme disease.

Your doctor will diagnose and treat you for a more serious form of Lyme based on your symptoms and a physical exam.

With more severe Lyme disease, you’ll need to take a longer course of antibiotics, a stronger dose of antibiotics, or both. Depending on what symptoms you have and how bad they are, you may need to take antibiotics for 14 to 28 days.

If you have meningitis or a severe form of Lyme carditis, your doctor may prescribe an intravenous antibiotic. A nurse will administer the IV drug at the hospital. Once your condition is stable, you can switch to the oral form of the drug.

If your symptoms don’t subside after your course of antibiotics, your doctor will likely prescribe a second course. This second course is typically given intravenously, at least at first, and will last up to a month. There is no evidence to support taking antibiotics to treat Lyme beyond two courses of treatment.

Outlook After Lyme Disease Treatment

Once treatment has started, most people treated for Lyme disease fully recover within a few weeks. This is especially true if Lyme is caught in the first few months, before it progresses to more serious forms.

Many patients will have some lingering symptoms of fatigue or joint pain even after they finish treatment. These symptoms should subside within a few weeks to a few months.

Around 10% of people with Lyme disease experience symptoms six months after the recommended antibiotic treatment. These symptoms may include joint pain, confusion, and fatigue. This condition is known as post-treatment Lyme disease syndrome.

There is currently no treatment for this condition, which some believe to be an autoimmune disorder. Fortunately, post-treatment Lyme disease syndrome typically improves on its own over time.

Beware of Unproven Lyme Disease Treatments

Some alternative providers suggest nonstandard therapies or very long courses of antibiotics. These treatments are not proven and can have dangerous side effects. If you delay treatment to try a non-antibiotic remedy, your symptoms can worsen and become more difficult to treat.

Remember, it is important to take the antibiotics as many times per day as prescribed. Even if your symptoms subside, be sure to finish the course of treatment. This ensures bacteria are fully eradicated and prevents bacteria from becoming resistant to the drugs.

Editor's Note: This article was originally published on August 30, 2021, and was last reviewed on August 25, 2025.