[{"@context":"https:\/\/schema.org\/","@type":"Article","@id":"https:\/\/share-dev.upmc.com\/2015\/12\/how-drug-addiction-happens\/#Article","mainEntityOfPage":"https:\/\/share-dev.upmc.com\/2015\/12\/how-drug-addiction-happens\/","headline":"How Drug Addiction Happens","name":"How Drug Addiction Happens","description":"Addiction is a compelling need for something, regardless of its destructive potential. Brain chemistry, environment and biological factors all play a role.","datePublished":"2015-12-11","dateModified":"2023-09-20","author":{"@type":"Organization","@id":"https:\/\/www.upmc.com\/services\/neurosurgery-regions","name":"Neurosurgery","url":"https:\/\/www.upmc.com\/services\/neurosurgery-regions","sameAs":"https:\/\/share-dev.upmc.com\/neurosurgery\/","parentOrganization":"UPMC"},"publisher":{"@type":"Organization","name":"UPMC HealthBeat","logo":{"@type":"ImageObject","@id":"https:\/\/share-dev.upmc.com\/wp-content\/uploads\/2019\/04\/UPMC-HealthBeat-Logo.png","url":"https:\/\/share-dev.upmc.com\/wp-content\/uploads\/2019\/04\/UPMC-HealthBeat-Logo.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/share-dev.upmc.com\/wp-content\/uploads\/2015\/12\/athlete-walking-towards-stadium-silhouette-picture-id1134843401.jpg","url":"https:\/\/share-dev.upmc.com\/wp-content\/uploads\/2015\/12\/athlete-walking-towards-stadium-silhouette-picture-id1134843401.jpg","height":327,"width":754},"url":"https:\/\/share-dev.upmc.com\/2015\/12\/how-drug-addiction-happens\/","about":["Neurosurgery and Brain Health"],"wordCount":503,"keywords":["brain","dopamine","drug addiction","National Institute on Drug Abuse","neurotransmitter"],"articleBody":"Understanding how people become addicted to drugs is an essential first step in confronting what has become a national crisis.For the individual, it is a compelling need — regardless of its destructive potential. For families and society as a whole, it is among the most serious of challenges.Overdose, poor health, broken homes, violence, and child abuse are just some of its negative effects. In addition, the economic burden from alcohol, illicit drugs, and nicotine cost the nation over $600 billion every year, says the National Institute on Drug Abuse (NIDA).Addiction and the BrainHow do people get hooked on drugs? At its most basic level, addiction is a disease affecting how the brain communicates with itself. Drugs do this in two ways.Some \u2014 like narcotics and cannabis \u2014 mimic the brain’s neurotransmitters. Methamphetamine, cocaine, and other stimulants overstimulate the brain’s reward system, causing it to produce excessive dopamine \u2014 its pleasure neurotransmitter. Either way, the brain reinforces behavior \u2014 drug use \u2014 with dopamine-induced pleasure. Once a person is addicted, the brain believes it “needs” this pleasure.Over time, it takes more drugs to achieve the desired effect. Believing it is supplying too much dopamine, the brain cuts back on its own production. Yet the reward system expects the same amount of this neurotransmitter, and the result is tolerance \u2014 where more of the drug is needed to maintain pleasurable dopamine levels.Drug addiction affects the brain in other ways. For example, another neurotransmitter called glutamate also is important in the brain’s pleasure\/reward system. Glutamate is important to the brain’s learning abilities, and drug-induced glutamate imbalances partly explain why people with addiction often suffer cognitive damage over time.The brain’s reward system isn’t the only area harmed by drugs. The NIDA says that images of the brain reveal areas responsible for judgment, decision-making, and behavior control allmay be damaged among people with addiction.Beyond the BrainAddiction is more than a chemical process in the brain. A number of combined risk factors increase the likelihood of using substances in the first place while reinforcing their ongoing use.Biological and environmental factors both affect a person’s vulnerability to substance use disorder. These factors include:Genetic predisposition.Gender.Ethnicity.Having a mental health disorder.Stress.Peer group pressure.History of physical and\/and sexual abuse.Socioeconomic status.Early drug addiction adversely affects adolescent brain development, and the younger a person begins the harder it can be to stop.Like many other chronic diseases, drug addiction is preventable. Prevention is in fact the single most effective approach.Ongoing outreach and education among vulnerable populations is essential. In spite of all of these compelling factors, drug addiction is a treatable disease.Whether it is nicotine, alcohol, heroin, or any other drug, help is available to those who want to quit.\u00a0Contact Western Psychiatric Institute and Clinic at 412-624-1000 for more information on addiction medicine, rehabilitation, and recovery.Editor's Note: This article was originally published on December 11, 2015, and was last reviewed on September 20, 2023."},{"@context":"https:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"2015","item":"https:\/\/share-dev.upmc.com\/2015\/#breadcrumbitem"},{"@type":"ListItem","position":2,"name":"12","item":"https:\/\/share-dev.upmc.com\/2015\/\/12\/#breadcrumbitem"},{"@type":"ListItem","position":3,"name":"How Drug Addiction Happens","item":"https:\/\/share-dev.upmc.com\/2015\/12\/how-drug-addiction-happens\/#breadcrumbitem"}]}]